38- year demographic study of central and peripheral giant cell granulomas of the gaws

Objective: the purpose of this study was to retrospectively analyze the demographic characteristics of patients with central peripheral giant cell granulomas [CGCGs] / [PGCGs] an Iranian population

Methods: in this 38-year retrospective study, the data were obtained from records of 1019 patients with CGCG and PGCG of the jaws referred to the Department of Oral and Maxillofacial, Pathology, Mashhad University of Medical Sciences, Iran between 1972 and 2010. Information regarding age distribution, gender, location of the lesion and clinical signs and symptoms was documented

Results: a total of 1019 patients were affected by giant cell granuloma lesions [GCGLs] including 435 CGCGs and 584 PGCGs. The mean age was 28.91 +/- 18.16. PGCGs and CGCGs had a peak of occurrence in the first and second decade of life respectively. A female predominance was shown in CGCG cases [57.70%], whereas PGCGs were more frequent in males [50.85%]. Five hundred and ninety eight cases of all giant cell lesions [58.7 %] occurred in the mandible. Posterior mandible was the most frequent site for both Lesions. The second most common site for PGCG was posterior maxilla [21%], whereas anterior mandible was involved in CGCG [19.45%]. The majority of patients were asymptomatic. Patient's age, location [mandible/maxilla] and bleeding were the influential variables on the type of the lesion

Conclusion: although the CGCGs share some histopathologic similarities with PGCGs, differences in demographic features may be observed in different populations

[Consistency rates of clinical and histopathologic diagnoses of mucocutaneous lesions in oral cavity]

Many mucocutaneous lesions of the oral cavity have similar clinical features and therefore the histpathologic findings are very important in correct diagnosis and differential diagnosis of each lesion. The aim of this study was to assess the agreement between clinical and histopathologic diagnoses in mucocutaneous lesions of the oral cavity during 30 years [1979-2009] in Mashhad dental School. In this retrospective study, a total of 334 patients with mucocutaneus lesions were analyzed in Mashhad dental school from1979 to 2009. Patient's data including age, gender, location, clinical diagnosis and histopathologic diagnosis were recorded. Data were analyzed through SPSS 11.5 Software. In this study, there was an agreement between clinical and histopathologic diagnoses in 295 subjects [77.5%] with oral mucocutaneus lesions. All subjects with pemphigoid and white spongy nevus showed total agreement between clinical and histopathologic diagnoses. Atrophic and pigmenteted lichen planus also showed the highest percentage of agreement in lichen planus groups. In mucocutaneous lesions, clinical, radiographic, and histopathologic findings are necessary for definitive diagnosis of mucocutaneous lesions

[Assessment of incidence of denture hyperplasia lesion in biopsies referred to department of oral and maxillofacial pathology of Mashhad dental school]

Complications resulting from removable denture consist of a wide range of oral mucosal lesions, the prevention of which and dealing with their complications are both the dentist's and the patient's responsibilities. The aim of this study was to evaluate the frequency of denture hyperplasia in Mashhad Dental School. In this descriptive-cross sectional study, we aimed to assess the incidence of denture hyperplasia lesions on biopsies received in the Department of Pathology of Mashhad Dental School since 1357 till 1387 Collected data were statistically analyzed using the SPSS software and tables and diagrams were generated. The lesions results from denture were 5.6% of all lesions. From 462 cases, 368 cases occurred in women and 94 in men. In 97.8% of patients IFH and in 2.2% of patients IPH were found. In this study, IFH with 452 cases were observed more frequently in the female [79.7%] than the male subjects and in the 5th and 6th decades [68.2%]. The common location of this lesion was mandible [69.9%] and anterior region [85.7%]. Lesion enlargement [4.6%], Pain and burning [9%] sensation were recognized as the two most common referring factors to the dentist associated with these lesions. In this study the IFH had the highest frequency and the IPH occurred only in a small percentage of lesions. Overall, the denture hyperplasia was more common in females in the 4th and 5th decades. The highest frequency of referring to the Dental School was between years 1367-1376 [54.9%]

Glandular odontogenic cyst of the posterior maxilla

The glandular odontogenic cyst is an uncommon developmental odontogenic cyst described as a distinct entity by Gardner et al. in 1988. The Glandular odontogenic cyst occurs more commonly in middle-aged people and has a predilection for the mandible. Only histopathological examinations allow for certain diagnosis of the cyst. The increased recurrence rate can be due to its multilocularity and incomplete removal of the lining following conservative treatment. This article presents a case of glandular odontogenic cyst in a 28-year-old male patient in the posterior region of the maxilla, which is quite rare

[Chondrosarcoma of the mandibular symphysis: report of a case]

Chondrosarcoma is a malignant tumor of cartilaginous origin. The most common type in the jaw is mesenchymal. Chondrosarcoma in maxillofacial region is an uncommon tumor and maxilla is more commonly affected than mandible. The aim of this paper is cases report of a rare chondrosarcoma of the mandible. A 65-year-old woman was referred to Oral Medicine Department of Mashhad dental school with swelling over the buccal and lingual aspect of the anterior mandible. Swelling had been present for 1 year and had increased gradually in six over time. The patient did not have any systemic disase and was not currently taking any medications. Extraoral examination did not reveal any obvious facial swelling, asymmetry or cervical lymphadenopathy. Intraoral examination revealed an exophitic nodular and tendered lesion with smooth and purple surface. IT was firm to rubbery in buccal aspect and bony in lingual surface with 3x3.5 diameters. Occlusal and panoramic radiographs revealed the multibular well defined and mixed radiolucent-redioopague lesion from right mandibular first premolar to left mandibular first premolar. Subperiosteal ossification is revealed in the occlusal cross sectional radiography. Histopathological examination revealed chondrosarcoma [grade I]. The patient was advised to undergo surgery, and the tumor was respected by segmental mandibulectomy. Clinical and radiographic feature at chondrosarcoma are varied, the incidence of this lesion in unusual location like anterior of jaw with a well-defined feature and ossification could lead to clinician error and delaying treatment. Considering age, course and invasion could be helpful in diagnosis

Assessment of VEGF, CD-31 and Ki-67 immunohistochemical markers in oral pyogenic granuloma: a comparison with hemangioma and inflammatory gingivitis

The aim of this study was to evaluate the expression of two angiogenic immune-makers [CD-31 and VEGF], and one proliferative immune-marker [Ki-67] in oral pyogenic gramulomas [PG], hemangiomas [Hem] and inflammatoey gingivitis [IG]. Sixty cases of PG, Hem and IG [twenty cases each] were examined. Immunohistochemical [IHC] staining was performed based on routine techniques. The microvessel density [MVD] index was also evaluated. The male to female ratio was 1:2. The mean age was 33.3 years old [ +/- 20.52]. The reactivity percentages for all three markers [CD-31, VEGF and Ki-67] were significantly higher in PG compared to Hem [56.8%, 13.8% and 23.0% vs. 28.3%, 7.0% and 5.4%, respectively]. The mean MVD in PG was also significantly higher than in Hem [26.1 +/- 0.11 vs. 13.6 +/- 0.08]. There was no statistically significant difference between PG and IG. The current study supports the common nature of pyogenic granulomas and inflammatory gingivits

[Evaluation of serum albumin level in chronic periodontitis]

Periodontal disease has been implicated as a risk factor for systemic diseases. There was a association between periodontal disease and serum albumin level in recent studies. The aim of this study was to evaluate the serum albumin concentration as a prognostic marker of the periodontal disease. In this cross-sectional study, 64 patients with chronic periodontitis, aged 20-50 years and 64 healthy control subjects with same age were selected. Dental and systemic stata were assessed for all subjects. Blood samples [2cc] were collected and COBASMIRA method was used to determine serum albumin level. The data were analyzed by One-Way ANOVA, Chi- square and t-tests. The mean serum albumin concentration was 5.05 +/- 2.7 gr/dl in chronic periodontitis and 4.40 +/- 0.39gr/dl in control group and the difference was significant [P=0.000]. Also there was a significant difference in albumin level between mild and moderate periodontitis [P=0.000]. Mean concentration of serum albumin level in periodontitis [mild, moderate, sever] was higher than control group

Gorlin-Goltz syndrome

We report a case of Gorlin-Goltz syndrome in a 21-year-old man. Gorlin-Goltz syndrome [basal cell nevus syndrome] is an infrequent hereditary disease with its prevalence varying from 1 / 57,000 to 1/250,000. It is principally characterized by a wide range of developmental abnormalities. Main clinical manifestations include multiple odontogenic keratocysts of the jaws, facial basal cell carcinomas and skeletal anomalies. The prevalence varies from 1/57,000 to 1/250,000